Osteopontina, una proteína involucrada en la progresión tumoral, y su participación en el desarrollo del carcinoma colorrectal.
Osteopontin, a protein involved in tumor progression, and its participation in the development of colorectal carcinoma.
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Introducción: La osteopontina es una proteína de la matriz extracelular que se ha encontrado sobre-expresada en varios tipos de tumores malignos, incluido el carcinoma colorrectal. Objetivo: Describir la evidencia científica disponible sobre la participación de osteopontina en la patogénesis del carcinoma colorrectal, y del posible uso de su expresión a nivel tisular, como biomarcador de esta neoplasia. Materiales y métodos: Se realizó una búsqueda bibliográfica de artículos en idioma inglés desde enero de 2012 hasta enero de 2018, en la base de datos Pubmed. Resultados: La revisión de la literatura permite decir que osteopontina está involucrada en casi todos los pasos de la progresión tumoral, y su sobre-expresión en el carcinoma colorrectal está asociada significativamente con altos grados tumorales, metástasis ganglionares y metástasis a distancia. Conclusión: Osteopontina podría servir como un biomarcador de pronóstico para el carcinoma colorrectal y tendría un papel importante en la predicción del resultado de la terapia clínica para esta neoplasia, se necesitan estudios más robustos que validen su uso en este sentido
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