Manejo del dolor mediado por receptores TRPV-1
TRPV-1 Receptors-mediated pain management
Barra lateral del artículo
PDF
FLIP
Contenido principal del artículo
Resumen
Introducción: los receptores transitorios sensibles a vanilloides-1 (TRPV-1), pertenecientes a la familia de receptores de potencial transitorio, desempeñan un papel importante en la excitación de neuronas nociceptiva y la consecuente generación de dolor lo que resulta una alternativa innovadora en el manejo multimodal del dolor neuropático.
Objetivo: el objetivo de esta revisión fue conocer el manejo del dolor mediado por receptores TRPV-1.
Resultados: existen ligandos endógenos como mediadores inflamatorios y exógenos como la capsaicina, que tienen por función modular la actividad de los receptores TRPV-1 a través de vías de señalización intracelular en neuronas sensitivas periféricas, ganglio dorsal e incluso a nivel central, llevando al efecto nociceptivo agudo y a un estado de neuroplasticidad en el tiempo.
Conclusión: inhibir la actividad de TRPV1 resulta una alternativa en el manejo del dolor neuropático. Siendo interesante e innovador en la población en la cual, otras vías de inhibición del dolor, no serían posible por factores individuales.
Palabras clave:
Descargas
Detalles del artículo
Referencias (VER)
Terminology - International Association for the Study of Pain (IASP), 2017, www.iasp-pain.org
Raja SN, Carr DB, Cohen M, Finnerup NB, Flor H, Gibson S, et al. The revised International Association for the Study of Pain definition of pain: concepts, challenges, and compromises. Pain. 2020;161(9):1976–82.
Dorner TE. Pain and chronic pain epidemiology. Wien Klin Wochenschr. 2018 Jan 21;130(1–2):1–3.
Rapti E, Damigos D, Apostolara P, Roka V, Tzavara C, Lionis C. Patients with chronic pain: evaluating depression and their quality of life in a single center study in Greece. BMC Psychol. 2019 Dec 21;7(1):86.
Chronic pain (primary and secondary) in over 16s: assessment of all chronic pain and management of chronic primary pain. National Institute for Health and Care Excellence (NICE), guideline [NG193] 7 April 2021.
Vascular and upper gastrointestinal effects of non- steroidal anti-inflammatory drugs: meta-analyses of individual participant data from randomised trials. Lancet. 2013 Aug; 382(9894):769–79.
Coxib and traditional NSAID Trialists' (CNT) Collaboration, Bhala N, Emberson J, Merhi A, Abramson S, Arber N, Baron JA, et al. Cardiovascular Safety of Celecoxib, Naproxen, or Ibuprofen for Arthritis. N Engl J Med. 2016 Dec 29;375(26):2519–29.
Nafziger AN, Barkin RL. Opioid Therapy in Acute and Chronic Pain. J Clin Pharmacol. 2018 Sep;58(9):1111– 22.
Hung C-Y, Tan C-H. TRP Channels in Nociception and Pathological Pain. In 2018. p. 13–27.
Zhao R, Tsang SY. Versatile Roles of Intracellularly Located TRPV1 Channel. J Cell Physiol. 2017 Aug;232(8):1957–65.
Pumroy RA, Fluck EC, Ahmed T, Moiseenkova-Bell VY. Structural insights into the gating mechanisms of TRPV channels. Cell Calcium. 2020 May;87:102168.
Satheesh NJ, Uehara Y, Fedotova J, Pohanka M, Büsselberg D, Kruzliak P. TRPV currents and their role in the nociception and neuroplasticity. Neuropeptides. 2016 Jun;57:1–8.
Basso L, Altier C. Transient Receptor Potential Channels in neuropathic pain. Curr Opin Pharmacol. 2017 Feb;32:9–15.
Caterina MJ, Schumacher MA, Tominaga M, Rosen TA, Levine JD, Julius D. The capsaicin receptor: a heat- activated ion channel in the pain pathway. Nature. 1997 Oct;389(6653):816–24.
Nagy I, Paule CC, White JPM. Molecular Mechanisms of TRPV1-Mediated Pain. In 2009. p. 75–99.
Benítez-Angeles M, Morales-Lázaro SL, Juárez- González E, Rosenbaum T. TRPV1: Structure, Endogenous Agonists, and Mechanisms. Int J Mol Sci. 2020 May 12;21(10):3421.
Bevan S, Quallo T, Andersson DA. TRPV1. In: Handbook of Experimental Pharmacology. 2014. p. 207– 45.
Kata Cseko, Balint Szalontai, Krisztina Pohoczky, Ivett Hegedus, Aniko Perkecz, Anita Illes, Aron Vincze, Jozsef Czimmer IS y ZH. Expression and inflammation-induced alterations of Transient Receptor Potential Vanilloid 1 (TRPV1) and Ankyrin 1 (TRPA1) ion channels in the human gastric mucosa. Neuropeptides. 2017;65:144–5.
Hilton JK, Rath P, Helsell CVM, Beckstein O, Van Horn WD. Understanding Thermosensitive Transient Receptor Potential Channels as Versatile Polymodal Cellular Sensors. Biochemistry. 2015 Apr 21;54(15):2401–13.
Srinivasan K. Biological Activities of Red Pepper ( Capsicum annuum ) and Its Pungent Principle Capsaicin: A Review. Crit Rev Food Sci Nutr. 2016 Jul 3;56(9):1488–500.
O’Neill J, Brock C, Olesen AE, Andresen T, Nilsson M, Dickenson AH. Unravelling the Mystery of Capsaicin: A Tool to Understand and Treat Pain. Dolphin AC, editor. Pharmacol Rev. 2012 Oct;64(4):939–71.
Modir JG, Wallace MS. Human Experimental Pain Models 3: Heat/Capsaicin Sensitization and Intradermal Capsaicin Models. In 2010. p. 169–74.
Hu F, Yang S, Zhao D, Zhu S, Wang Y, Li J. Moderate extracellular acidification inhibits capsaicin-induced cell death through regulating calcium mobilization, NF-κB translocation and ROS production in synoviocytes. Biochem Biophys Res Commun. 2012 Jul;424(1):196–200.
Malek N, Pajak A, Kolosowska N, Kucharczyk M, Starowicz K. The importance of TRPV1-sensitisation factors for the development of neuropathic pain. Mol Cell Neurosci. 2015 Mar;65:1–10.
Marrone MC, Morabito A, Giustizieri M, Chiurchiù V, Leuti A, Mattioli M, et al. TRPV1 channels are critical brain inflammation detectors and neuropathic pain biomarkers in mice. Nat Commun. 2017 Aug 10;8(1):15292.
Unsworth B, Aziz Q, Holzer P, Hobson A. Reproducibility of viscero-visceral and viscerosomatic sensitisation induced by intraduodenal capsaicin infusion. 2007. 41–42 p.
Kimihito Tashima, Kazuki Hashimoto, Teturo Kamoshita, Akio Takagaki K, Matsumoto SH. Activation of Luminal Chemosensor TRPV1 by Capsaicin Increases Gastric Motility in Conscious Mice Measured by 13C- Acetic Acid Breath Test. Gastroenterology. 2013;144(5):S-194-S-194.
Yen C-M, Wu T-C, Hsieh C-L, Huang Y-W, Lin Y-W. Distal Electroacupuncture at the LI4 Acupoint Reduces CFA-Induced Inflammatory Pain via the Brain TRPV1 Signaling Pathway. Int J Mol Sci. 2019 Sep 10;20(18):4471.
Pérez de la Fuente T, Cárcamo Hermoso C. El parche de capsaicina: una nueva herramienta para el tratamiento del dolor neuropático tras cirugía mamaria. Rev Senol y Patol Mamar. 2020 Jul.
Chung M-K, Campbell J. Use of Capsaicin to Treat Pain: Mechanistic and Therapeutic Considerations. Pharmaceuticals. 2016 Nov 1;9(4):66.
Mason L, Moore RA, Derry S, Edwards JE, McQuay HJ. Systematic review of topical capsaicin for the treatment of chronic pain. BMJ. 2004 Apr 24;328(7446):991.
Geppetti P. Transient receptor potential channels as novel drug targets. Clin Ther. 2013;35(8):e-117-e-117.
Czaja K, Burns GA, Ritter RC. Capsaicin-induced neuronal death and proliferation of the primary sensory neurons located in the nodose ganglia of adult rats. Neuroscience. 2008 Jun;154(2):621–30.
Simone DA, Nolano M, Johnson T, Wendelschafer- Crabb G, Kennedy WR. Intradermal Injection of Capsaicin in Humans Produces Degeneration and Subsequent Reinnervation of Epidermal Nerve Fibers: Correlation with Sensory Function. J Neurosci. 1998 Nov 1;18(21):8947–59.
Guedes V, Castro JP, Brito I. Topical capsaicin for pain in osteoarthritis: A literature review. Reumatol Clínica. 2018 Jan;14(1):40–5.
Derry S, Rice AS, Cole P, Tan T, Moore RA. Topical capsaicin (high concentration) for chronic neuropathic pain in adults. Cochrane Database Syst Rev. 2017 Jan 13.
Joseph EK, Reichling DB, Levine JD. Shared Mechanisms for Opioid Tolerance and a Transition to Chronic Pain. J Neurosci. 2010 Mar 31;30(13):4660–6.
Basso L, Aboushousha R, Fan CY, Iftinca M, Melo H, Flynn R, et al. TRPV1 promotes opioid analgesia during inflammation. Sci Signal. 2019 Apr 2;12(575):eaav0711.
Gorham L, Just S, Doods H. Somatostatin 4 receptor activation modulates TPRV1 currents in dorsal root ganglion neurons. Neurosci Lett. 2014 Jun;573:35–9.
Ji GC, Zhou ST, Shapiro G, Reubi JC, Carlton SM, Jurczyk S. Analgesic activity of a non-peptide imidazolidinedione somatostatin agonist: In vitro and in vivo studies in rat. Pain. 2006 Sep;124(1):34–49.
Rami HK, Thompson M, Wyman P, Jerman JC, Egerton J, Brough S, et al. Discovery of small molecule antagonists of TRPV1. Bioorg Med Chem Lett. 2004 Jul;14(14):3631–4.
Bevan S, Quallo T, Andersson DA. TRPV1. In: Handb Exp Pharmacol. Springer, Berlin Heidelberg; 2014. p. 207–45.
Kojima I, Nagasawa M. TRPV2. In: Handb Exp Pharmacol. Springer, Berlin Heidelberg; 2014. p. 247– 72.
Yang P, Zhu MX. TRPV3. In: Handb Exp Pharmacol. Springer, Berlin Heidelberg; 2014. p. 273–91.
Garcia-Elias A, Mrkonjić S, Jung C, Pardo-Pastor C, Vicente R, Valverde MA. The TRPV4 Channel. In: Mammalian Transient Receptor Potential (TRP) Cation Channels. Springer, Berlin Heidelberg; 2014. p. 293–319.
Na T, Peng J-B. TRPV5: A Ca2+ Channel for the Fine- Tuning of Ca2+ Reabsorption. In: Handb Exp Pharmacol. Springer, Berlin Heidelberg; 2014. p. 321–57.
Rosenthal W, Offermanns S. TRPV5 and TRPV6. In: Encyclopedia of Molecular Pharmacology. Springer, Berlin Heidelberg; 2008. p. 1246–1246.
Wissenbach U, Niemeyer BA. TRPV6. In: Transient Receptor Potential (TRP) Channels. Springer, Berlin Heidelberg; 2007. p. 221–34.
Fecher-Trost C, Weissgerber P, Wissenbach U. TRPV6 Channels. In: Mammalian Transient Receptor Potential (TRP) Cation Channels. Springer, Berlin Heidelberg; 2014. p. 359–84.
Citado por
