Cambios moleculares en la remodelación cardiaca por síndrome metabólico.
Molecular changes in cardiac remodeling due to metabolic syndrome.
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Introducción: el síndrome metabólico (SM) es un conjunto de anormalidades caracterizadas por el aumento de presión arterial, elevación de la glucemia en ayuno, dislipidemias, obesidad y/o diabetes, en donde se encuentran implicadas diversas moléculas que participan en la comunicación intracelular. Objetivo: se describe la función y mecanismo de señalización intracelular que involucra a algunas de las moléculas que llevan a cabo procesos de remodelación cardiaca y son de especial interés como biomarcadores. Métodos: se realizó una selección de literatura que nos describiera la participación de las moléculas en el proceso de remodelación cardiaca como resultado del SM. Conclusiones: el SM y la falla cardiaca se encuentra íntimamente vinculados por la modulación de diversas vías de señalización intracelular que contribuyen a la remodelación cardiaca, generando cambios estructurales modificando la fisiopatología del cardiomiocito.
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