Concordancia diagnóstica clínico-histopatológica en los tumores de glándulas salivales mayores

Concordancia diagnóstica clínico-histopatológica en los tumores de glándulas salivales mayores

Contenido principal del artículo

Tonny Alberto Torres Tabares
Enrique Carlos Ramos Clason
Volney Enrique Bello Avena
Rosa Milanés Pérez

Resumen

Objetivo: estimar el grado de concordancia diagnóstica entre los aspectos clínicos y los hallazgos histopatológicos en pacientes con tumores de glándulas salivales mayores.
Metodología: se realizó un estudio descriptivo en el Hospital Universitario del Caribe, Cartagena, Colombia, 2006 - 2010. Los datos se obtuvieron por medio de la revisión de historias clínicas de 64 pacientes. Los datos fueron almacenados y analizados por medio del programa estadístico EPI – INFO versión 3.5.1. Se realizó la comparación de proporciones para variables cualitativas y comparación de medias o medianas según criterios de normalidad para las cuantitativas, se estimaron los parámetros de validez diagnóstica de algunos signos clínicos sugestivos de malignidad.
Resultados: el sexo femenino fue el más frecuentemente afectado con 64,1% de los casos. La localización más frecuente fue la glándula parótida. Los signos clínicos sugestivos de malignidad que mostraron mayor validez fueron el compromiso de piel, de pares craneales, la no movilidad de la masa, el dolor y la presencia de adenopatías cervicales. La validez del criterio clínico del otorrinolaringólogo fue del 92%.
Conclusión: el examen físico y el criterio clínico del especialista son la base para una adecuada orientación diagnóstica y de tratamiento, sin embargo en ausencia de los signos clínicos sugestivos de malignidad, esta no puede ser descartada. Rev.cienc. biomed. 2011; 2 (2): 241-248

Palabras clave:

Descargas

Los datos de descargas todavía no están disponibles.

Detalles del artículo

Referencias (VER)

Eveson JW, Cawson RA. Salivary gland tumors: A review of 2410 cases with particular reference to histological types, site, age and sex distribution. J Pathol 1985;146: 51.

Abiose BO, Oyejide O, Ogunniyi J. Salivary gland tumors in Ibadan, Nigeria: A study of 295 cases. Afr J Med Med Sci 1990; 19: 195.

Arotiba GT. Salivary gland neoplasms in Lagos, Nigeria. West Afr J Med 1996; 15: 11.

Kolude B, Lawoyin JO, Akang EE. Salivary gland neoplasms: A 21-year review of cases seen at University College Hospital, Ibadan. Afr J Med Med Sci 2001; 30: 95.

Vargas PA, Gerhard R, Araujo Filho VJ, et al. Salivary gland tumors in a Brazilian population: A retrospective study of 124 cases. Rev Hosp Clin Fac Med S Paulo 2002; 57: 271.

Masanja MI, Kalyanyama BM, Simon EN. Salivary gland tumors in Tanzania. East Afr Med J 2003; 80: 429.

Kamulegeya A, Kasangaki A. Neoplasms of the salivary gland: A descriptive retrospective study of 142 cases—Mulgao Hospital Uganda. J Contemp Dent Pract 2004;15:16.

Frade-Gonzalez C, Lozano Ramirez A, Garcia Caballero T, et al. Epidemiological study of salivary gland tumors. Rev Laryngol Otol Rhinol 1999; 120: 331.

Pinkston JA, Cole P: Incidence rates of salivary gland tumors. Results from a population-based study. Otolaryngol Head Neck Surg 1999;120:834.

Pacheco-Ojeda L, Domeisen H, Narrvaez M, et al. Malignant salivary gland tumors in Quito, Ecuador. ORL J Otorhinolaryngol Relat Spec 2000;62:296.

Hanna EY, Suen JY. Malignant tumors of the salivary glands. In: Myers EN, Suen JY, Myers JN, et al ed. Cancer of the Head and Neck, Philadelphia: Saunders 2003; 475 - 510.

Keyes Jr JW, Harkness BA, Greven KM, et al. Salivary gland tumors: pretherapy evaluation with PET. Radiology 1994; 192: 99 - 102.

Holsinger FC, Bui DT. Anatomy, function, and evaluation of the salivary glands. In: Myers EN, Ferris RL, et al ed. Salivary glands disorders, pittsburgh: Springer 2007; 1: 16.

Vuhahula EA. Salivary gland tumors in Uganda: Clinical pathological study. Afr Health Sci 2004; 4: 15.

Waldron CA, el-Mofty SK, Gnepp DR. Tumors of the intraoral minor salivary glands: A demographic and histologic study of 426 cases. Oral Surg Oral Med Oral Pathol 1988; 66: 323.

Otoch EC, Johnson NW, Olasoji H, et al. Salivary gland neoplasms in Maiduguri, north-eastern Nigeria. Oral Dis 2005; 11: 386.

Jansisyanont P, Blanchaert RH Jr, Ord RA. Intraoral minor salivary gland neoplasms: A single institution experience of 80 cases. Int J Oral Maxillofac Surg 2002; 31: 257.

Ledesma-Montes C, Garces-Ortiz M. Salivary gland tumors in a Mexican sample: A retrospective study. Med Oral 2002; 7: 324.

Jaber MA: Intraoral minor salivary gland tumors. A review of 75 cases in a Libyan population. Int J Oral Maxillofac Surg 2006; 35: 150.

Dardick I, Byard RW, Carnegie JA. A review of the proliferative capacity of major salivary glands and the relationship to current concepts of neoplasia in salivary glands. Oral Surg Oral Med Oral

Pathol 1990; 69: 53 - 67.

El-Naggar AK, Callender D, Coombes MM, et al. Molecular genetic alterations in carcinoma expleomorphic adenoma: a putative progression model?. Genes Chromosomes Cancer 2000; 27:162 - 168.

Horn-Ross PL, Morrow M, Ljung BM. Menstrual and reproductive factors for salivary gland cancer risk in women. Epidemiology 1999; 10: 528 - 530.

Toida M, Balazs M, Mori T, et al. Analysis of genetic alterations in salivary gland tumors by comparative genomic hybridization. Cancer Genet Cytogenet 2001; 127: 34 - 37.

Land CE, Saku T, Hayashi Y, et al. Incidence of salivary gland tumors among atomic bomb survivors, 1950-1987: evaluation of radiation-related risk. Radiat Res 1996; 146: 28 - 36.

Toida M, Shimokawa K, Makita H, et al. Intraoral minor salivary gland tumors: A clinicopathological study of 82 cases. Int J Oral Maxillofac Surg 2005; 34: 528.

Langdon JD: Tumors of the salivary glands. Clinical analysis of 68 cases. J Oral Maxillofac Surg 1985; 43: 688.

Pinkston JA, Cole P: Cigarette smoking and Warthin’s tumor. Am J Epidemiol 1996; 144:183 - 187.

Nagao T, Sugano I, Ishida Y, et al. Sialolipoma: A report of 7 cases of a new variant of salivary gland lipoma. Histopathology 2001; 38: 30.

Rivera-Bastidas H, Ocanto RA, Acevedo AM. Intraoral minor salivary glands: A retrospective study of 62 cases in a Venezuelan population. J Oral Pathol Med 1996; 25: 1.

Eveson JW, Cawson RA. Salivary gland tumours. A review of 2410 cases with particular reference to histological types, site, age and sex distribution. J Pathol 1985; 146: 51 - 58.

Ellis GL, Auclair PL. Atlas of Tumor Pathology, Tumors of the Salivary Glands. Washington DC, Armed Forces Institute of Pathology, 1996.

Renehan A, Gleave EN, Hancock BD, et al. Long-term follow-up of over 1000 patients with salivary gland tumours treated in a single centre. Br J Surg 1996; 83: 1750 - 1754.

Spitz MR, Batsakis JG. Major salivary gland carcinoma. Descriptive epidemiology and survival of 498 patients. Arch Otolaryngol 1984; 110: 45 - 49.

Spiro RH: Salivary neoplasms. overview of a 35-year experience with 2,807 patients. Head Neck Surg 1986; 8: 177- 184.

Pinkston JA, Cole P. Incidence rates of salivary gland tumors: results from a population-based study. Otolaryngol Head Neck Surg 1999; 120: 834 - 840.

Hunter RM, Davis BW, Gray Jr GF, et al. Primary malignant tumors of salivary gland origin. A 52-year review. Am Surg 1983; 49:82 - 89.

Ito FA, Ito K, Vargas PA, et al. Salivary gland tumors in a Brazilian population: A retrospective study of 496 cases. Int J Oral Maxillofac Surg 2005; 34: 533.

Neely MM, Rohrer MD, Young SK. Tumors of minor salivary glands and the analysis of 106 cases. J Okla Dent Assoc 1996; 86: 50.

Satko I, Stanko P, Longauerova I. Salivary gland tumors treated in the stomatological clinics in Bratislava. J Craniomaxillofac Surg 2000; 28: 56.

Takahashi H, Fujita S, Tsuda N, et al. Intraoral minor salivary gland tumors: A demographic and histologic study of 200 cases. Tohoku J Exp Med 1990; 161: 111.

Yih WY, Kratochvil GJ, Stewart JC. Intraoral minor salivary gland neoplasms: Review of 213 cases. J Oral Maxillofac Surg 2005; 63: 805.

Andersen LJ, Therkildsen MH, Ockelmann HH, et al. Malignant epithelial tumors in the minor salivary glands, the submandibular gland, and the sublingual gland. Prognostic factors and treatment results. Cancer 1991; 68: 2431 – 2437.

Ellis GL, Auclair PL, editors. Tumors of the salivary glands. AFIP atlas of tumor pathology, 4th series, fascicle 9. Silver Spring, MD: ARP Press; 2008.

Hocwald E, Yoo GH, Adsay V, et al. Prognostic factors in major salivary gland cancer. Laryngoscope 2001;111: 1434 –1439.

Lima RA, Tavares MR, Dias FL, et al. Clinical prognostic factors in malignant parotid gland tumors. Otolaryngol Head Neck Surg 2005; 133: 702 – 708.

Batsakis JG, editor. Tumours of the head and neck. Clinical and pathological considerations. 2nd ed. Baltimore/London: Williams & Wilkins; 1982.

Calzada G, Hanna E. Benign neoplasms of the salivary glands. Cummings otolaryngology head and neck surgery 5th ed.2010; 87: 1164 - 1165.

Chen I, Tu H. Pleomorphic adenoma of the parotid gland metastasizing to the cervical lymph node. Otolaryngol Head Neck Surg 2000; 122: 455 – 457.

Guzzo M, Locati L, et al. Major and salivary gland tumors. Critical reviews in Oncology-Hematology 2010; 74: 134 – 148.

Cermik TF, Mavi A, Acikgoz G, et al. FDG PET in detecting primary and recurrent malignant salivary gland tumors. Clin Nucl Med 2007; 32: 286 –2 91.

Jackel MC, Reischl A, Huppert P. Efficacy of radiologic screening for distant metastases and second primaries in newly diagnosed patients with head and neck cancer. Laryngoscope 2007; 117: 242 – 247.