El síndrome de Lambert-Eaton una sinapticopatía presináptica

Roberto Guerrero Figueroa

DOI: https://doi.org/10.32997/rcb-2010-2741

Resumen

Un total de cinco pacientes con diagnóstico de síndrome miasténico de Lambert-Eaton fueros estudiados utilizando técnicas electrofisiológicas. Los resultados presentados en este artículo demuestran que la patogenia del síndrome de LEMS es producida por un mecanismo autoinmune, que afecta la sinapsis neuromuscular, bloqueando a través de anticuerpos subunidades de los canales iónicos terminales axonales para el Ca2+ y alterando los mecanismos básicos de recaptación de Ach a nivel de receptores presinápticos. Rev.cienc.biomed. 2010, 1(1): 128-135.


Palabras clave

Síndrome de Lambert-Eaton; canales de calcio; receptores presinápticos;

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